منابع مشابه
The athymic nude rat. III. Natural cell-mediated cytotoxicity.
Homozygous rnuirnu and heterozygous +/mu rats were investigated and compared with each other for the existence of natural cell-mediated cytotoxicity. Investigated were total, adherent, and nonadherent cell populations from spleen, peritoneal cavity, and mesenteric lymph node. The natural killer (NK) cell activity was measured in a 4-hr SICr-release assay with a xenogeneic murine YAC lymphoma ta...
متن کاملHerpetic keratitis in athymic (nude) mice.
The inflammatory response to herpes simplex virus infection of the cornea was studied in athymic nude (nu/nu) and heterozygote (nu/+) BALB/c mice. Although athymic mice were highly susceptible to HSV infection and died 13 to 17 days after corneal inoculation, they failed to develop necrotizing keratitis of the cornea. Heterozygote mice survived the initial virual infection, but many of these mi...
متن کاملCellular requirements for renal allograft rejection in the athymic nude rat
This study has examined the ability of adoptively transferred CD4+ and CD8+ T cells to mediate rejection of a fully allogeneic DA renal graft in the PVG nude rat. Transfer, at the time of transplantation, of naive CD4+ T cells caused rapid graft rejection and primed CD4+ cells were several times more potent. In contrast, naive or specifically sensitized CD8+ cells were entirely ineffective at m...
متن کاملHeterotransplantation of retinoblastoma into the athymic "nude" mouse.
Fresh surgical specimens of retinoblastoma were successfully transplanted into the anterior chamber of the "nude" mouse (a homozygous mutant, nu/nu, with a severe defect in cellular immunity), filling the eyes but failing to grow subcutaneously. Retinoblastoma cells from an established cell line, Y-79,1 spread from the intraocular injection site to invade the orbit, optic nerve, and brain and f...
متن کاملHeterotransplantation of human choroidal melanoma into the athymic "nude" mouse.
The investigation of the structure and behavior of malignant melanoma of the uveal tract in man has been limited by the lack of a ready source of human tumor and an animal model in which the tumor resembles that in the human choroid. We now report the observation that fresh surgical specimens of human choroidal melanoma can be successfully transplanted into the posterior segment of the "nude" m...
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ژورنال
عنوان ژورنال: Clinical Immunology and Immunopathology
سال: 1980
ISSN: 0090-1229
DOI: 10.1016/0090-1229(80)90084-7